Rapid response to cyclosporine therapy and sustained remission in large granular lymphocyte leukemia.

Considering the recent interest in large granular lymphocyte (LGL) proliferation and the frequent association of severe granulopenia (“T-y neutropenia”) with T-LGL leukemia leading to intractable and often fatal infections, we wish to describe a case of T-LGL leukemia with absolute agranulocytosis which showed an excellent, rapid, and sustained response to nontoxic doses of cyclosporine after failing steroid and growth-factor therapy.